Common Genetic Variants in ANK2 Modulate QT Interval
نویسندگان
چکیده
منابع مشابه
Common genetic variants in ANK2 modulate QT interval: results from the KORA study.
BACKGROUND Spatial and timely variations in QT interval, even within its normal range, may underlie susceptibility to cardiac arrhythmias and sudden cardiac death. Given its important role in cardiac electrophysiology, we hypothesized that common genetic variation in ankyrin-B gene (ANK2) might modify QT interval length. METHODS AND RESULTS The study population consisted of 1188 participants ...
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BACKGROUND Ethnic differences in cardiac arrhythmia incidence have been reported, with a particularly high incidence of sudden cardiac death and low incidence of atrial fibrillation in individuals of African ancestry. We tested the hypotheses that African ancestry and common genetic variants are associated with prolonged duration of cardiac repolarization, a central pathophysiological determina...
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BACKGROUND Although sudden cardiac death (SCD) is heritable, its genetic underpinnings are poorly characterized. The QT interval appears to have a graded relationship to SCD, and 35% to 45% of its variation is heritable. We examined the relationship among recently reported common genetic variants, QT interval, and SCD. METHODS AND RESULTS We genotyped 15 common (minor allele frequency >1%) ca...
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Altered myocardial repolarization is one of the important substrates of ventricular tachycardia and fibrillation. The influence of rare gene variants on repolarization is evident in familial long QT syndrome. To investigate the influence of common gene variants on the QT interval we performed a linkage disequilibrium based SNP association study of four candidate genes. Using a two-step design w...
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Christopher Newton-Cheh1–3,22, Mark Eijgelsheim4,22, Kenneth M Rice5,22, Paul I W de Bakker2,6,22, Xiaoyan Yin3,7, Karol Estrada8, Joshua C Bis9,10, Kristin Marciante9,10, Fernando Rivadeneira4,8, Peter A Noseworthy1, Nona Sotoodehnia9,11, Nicholas L Smith9,12,13, Jerome I Rotter14, Jan A Kors15, Jacqueline CM Witteman4,16, Albert Hofman4,16, Susan R Heckbert9,12,17, Christopher J O’Donnell3,18...
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ژورنال
عنوان ژورنال: Circulation: Cardiovascular Genetics
سال: 2008
ISSN: 1942-325X,1942-3268
DOI: 10.1161/circgenetics.108.792192